Full name: programmed cell death 10

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: CCM3; TFAR15

Summary: This gene encodes an evolutionarily conserved protein associated with cell apoptosis. The protein interacts with the serine/threonine protein kinase MST4 to modulate the extracellular signal-regulated kinase (ERK) pathway. It also interacts with and is phosphoryated by serine/threonine kinase 25, and is thought to function in a signaling pathway essential for vascular developent. Mutations in this gene are one cause of cerebral cavernous malformations, which are vascular malformations that cause seizures and cerebral hemorrhages. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

Expression: Ubiquitous expression in colon (RPKM 13.1), lymph node (RPKM 11.6) and 25 other tissues

Gene size: 51595bp

Exon count: 10