Full name: dual specificity phosphatase 10

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: MKP-5; MKP5

Summary: Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAP kinase superfamily, which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAP kinases, different tissue distribution and subcellular localization, and different modes of expression induction by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

Expression: Broad expression in liver (RPKM 11.1), bone marrow (RPKM 10.7) and 22 other tissues

Gene size: 40666bp

Exon count: 6