Full name: leucine zipper tumor suppressor 1

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: F37; FEZ1

Summary: This gene encodes a tumor suppressor protein that is ubiquitously expressed in normal tissues. In uveal melanomas, expression of this protein is silenced in rapidly metastasizing and metastatic tumor cells but has normal expression in slowly metastasizing or nonmetastasizing tumor cells. This protein may have a role in cell-cycle control by interacting with the Cdk1/cyclinB1 complex. This gene is located on chromosomal region 8p22. Loss of heterozygosity (LOH) in the 8p arm is a common characteristic of many types of cancer. [provided by RefSeq, Nov 2009]

Expression: Broad expression in testis (RPKM 4.1), brain (RPKM 3.1) and 19 other tissues

Gene size: 57799bp

Exon count: 8