Full name: serine peptidase inhibitor, Kunitz type 2

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: DIAR3; HAI-2; HAI2; Kop; PB

Summary: This gene encodes a transmembrane protein with two extracellular Kunitz domains that inhibits a variety of serine proteases. The protein inhibits HGF activator which prevents the formation of active hepatocyte growth factor. This gene is a putative tumor suppressor, and mutations in this gene result in congenital sodium diarrhea. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

Expression: Broad expression in colon (RPKM 172.2), thyroid (RPKM 135.2) and 22 other tissues

Gene size: 28043bp

Exon count: 7