Full name: SH2B adaptor protein 2

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: APS

Summary: The protein encoded by this gene is expressed in B lymphocytes and contains pleckstrin homology and src homology 2 (SH2) domains. In Burkitt's lymphoma cell lines, it is tyrosine-phosphorylated in response to B cell receptor stimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to the Shc/Grb2 pathway. [provided by RefSeq, Jun 2009]

Expression: Broad expression in lymph node (RPKM 2.3), spleen (RPKM 2.2) and 22 other tissues

Gene size: 36571bp

Exon count: 13