Full name: bleomycin hydrolase

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: Bh; Bmh

Summary: The encoded protein is a cytoplasmic cysteine peptidase involved in inactivation of bleomycin, a glycopeptide which is a component of combination chemotherapy regimens for cancer. This encoded enzyme is highly conserved, and it contains the signature active site residues of cysteine protease papain superfamily enzymes. It is postulated that this enzyme has protective effects against bleomycin-induced pulmonary fibrosis and bleomycin tumor resistance. [provided by RefSeq, Jan 2010]

Expression: Ubiquitous expression in CNS E11.5 (RPKM 34.4), CNS E14 (RPKM 21.5) and 25 other tissues

Gene size: 41734bp

Exon count: 12