Full name: cadherin 11

Gene type: protein coding

RefSeq status: REVIEWED

Also known as: CAD11; CDHOB; ESWS; OB; OSF-4; TBHS2

Summary: This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Expression of this particular cadherin in osteoblastic cell lines, and its upregulation during differentiation, suggests a specific function in bone development and maintenance. [provided by RefSeq, Jul 2008]

Expression: Broad expression in ovary (RPKM 46.8), placenta (RPKM 33.6) and 14 other tissues

Gene size: 179992bp

Exon count: 15