HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 [ Homo sapiens (human) ]
Source: NCBI Gene (ID 10021)
Source: NCBI Gene (ID 10021)
Symbol: HCN4
Full name: hyperpolarization activated cyclic nucleotide gated potassium channel 4
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Also known as: BRGDA8; EIG18; SSS2
Summary: This gene encodes a member of the hyperpolarization-activated cyclic nucleotide-gated potassium channels. The encoded protein shows slow kinetics of activation and inactivation, and is necessary for the cardiac pacemaking process. This channel may also mediate responses to sour stimuli. Mutations in this gene have been linked to sick sinus syndrome 2, also known as atrial fibrillation with bradyarrhythmia or familial sinus bradycardia. Two pseudogenes have been identified on chromosome 15. [provided by RefSeq, Oct 2008]
Expression: Biased expression in testis (RPKM 3.3), heart (RPKM 1.0) and 3 other tissues
Orthologs: mouse
Gene size: 49100bp
Exon count: 9