Electron microscopy and microanalysis of a subcutaneous heterotopic calcification.
Calcif Tissue Int, 1983/9;35(6):723-7.
PMID: 6652547
Impact factor: 4
Abstract
This paper reports the study of a subcutaneous heterotopic calcification from a patient with Thibierge-Weissenbach's syndrome, a type of creeping scleroderma included in the CRST syndrome. These local deposits, whose origin is still unknown, are commonly considered to be a classic apatite phase. Using SEM, high resolution TEM, electron diffraction, infrared spectrometry, and SEM and TEM microanalysis, it is demonstrated that this material is highly heterogeneous and appears in a nonstoichiometric, carbonated, calcium ion-deficient apatitic solid phase. Our study shows the coexistence of dense globules presenting an ill-organized, more or less amorphous phase (ACP) or microcrystalline (OCP, beta tricalcium phosphate), with scattered apatite crystals, and of interglobular apatite crystals with a good cristallinity.
MeSH terms
Aged; Apatites; Calcinosis; Electron Probe Microanalysis; Female; Humans; Microscopy, Electron; Scleroderma, Systemic; Skin; Spectrophotometry, Infrared
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