Cell migration: PKA and RhoA set the pace.
Curr Biol, 2011/8/09;21(15):R596-8.
Newell-Litwa KA[1], Horwitz AR
Affiliations
PMID: 21820627DOI: 10.1016/j.cub.2011.06.032
Impact factor: 10.9
Abstract
A new study shows that protein kinase A (PKA) activity establishes a signaling loop that governs protrusion-retraction cycles in migrating cells. PKA activity near the leading edge of protrusions phosphorylates RhoA and inhibits its activity via increased association with RhoGDI.
MeSH terms
Animals; Cell Movement; Cyclic AMP-Dependent Protein Kinases; Phosphorylation; rhoA GTP-Binding Protein
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