The P323L substitution in the SARS-CoV-2 polymerase (NSP12) has a selective advantage in humans and non-human primates that correlates with a change in phenotype in vitro
Source: NCBI BioProject (ID PRJNA789459)
Source: NCBI BioProject (ID PRJNA789459)
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Project name: Severe acute respiratory syndrome coronavirus 2
Description: The mutational landscape of SARS-CoV-2 varies at both the dominant viral genome sequence and minor genomic variant population. An early change associated with an increase in transmissibility was the D614G substitution in the spike protein. This appeared to be accompanied by a P323L substitution in the viral polymerase (NSP12), but this latter change was not thought to be under strong selective pressure.
Data type: raw sequence reads
Sample scope: Monoisolate
Organization: University of Liverpool
Last updated: 2021-12-16