Project name: Lysine benzoylation is a novel histone mark [RNA-seq]

Description: We identified and characterized a previously undescribed histone mark, lysine benzoylation. This histone mark could be modulated by sodium benzoate (SB), an FDA-approved drug and a widely used chemical food preservative, via generation of benzoyl CoA. By ChIP-seq and RNA-seq analysis, we demonstrate that histone lysine benzoylation marks are involved in regulation of gene expression and associated with diverse biological processes. This study therefore reveals a new type of physiological relevant histone mark and identifies non-conical functions of a widely used chemical food preservative.Overall design: We have a control group and a SB-treated group. For RNA-seq, each group contains 4 bilogical replicates. For ChIP-seq, each group contains an input, a lysine acetylation, and a lysine benzoylation samples.

Data type: Transcriptome or Gene expression

Sample scope: Multiisolate

Relevance: Medical

Last updated: 2017-12-22