Project name: RNAseq of hypnozoites and schizonts in the MPCC system

Description: Upon P. vivax infection, dormant liver stage forms, hypnozoites, linger for weeks to months and then relapse to cause recurrent blood stage infection. Very little is known about the hypnozoite: Definitive biomarkers are lacking and in vitro platforms that support phenotypic studies have not been available. Here, we recapitulate the entire liver stage life cycle of P. vivax in vitro in a multiwell format and assay the hypnozoite transcriptomeOverall design: Determination of differentially expressed genes between hypnozoite enriched and mixed populations

Data type: Transcriptome or Gene expression

Sample scope: Multiisolate

Relevance: Medical

Last updated: 2017-12-13