Gene expression profiles of mouse neutrophils stimulated with cancer stem cell-derived microvesicles
Source: NCBI BioProject (ID PRJNA395999)
Source: NCBI BioProject (ID PRJNA395999)
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Project name: Mus musculus
Description: Tumor-infilitrated myeloid cells have been implicated for tumor-host interaction and therapeutic resistance. However, impacts of tumor-secreted microvesicles on host neutrophils remain unknown. By examining transcriptome profiles of tumor exosome-stimulated neutrophils, key genes regulating tumor immunity will be elucidated to develope coping strategies for combating pathological tumor-host interaction.Overall design: A colon cancer cell line, CT26, is used to enrich cancer stem cells by a defined stem cell medium (SCM) cultivation. The tumor exosomes of cancer stem cells are collected from SCM by ultracentrifugation for neutrophil treatment.
Data type: Transcriptome or Gene expression
Sample scope: Multiisolate
Relevance: ModelOrganism
Organization: WLH LAB, The Ph.D Program for Translational Medicine, Taipei Medical University
Last updated: 2017-07-27