Project name: Homo sapiens

Description: Epigenetics may help understanding the molecular mechanisms of atherosclerosis as genetic predisposition explains only part of cardiovascular disease risk. In particular, DNA methylation, a reversible and highly regulative DNA modification could contribute to disease onset and progression as it functions as effector for environmental impacts, including dietary and life-style, similarly to risk factors for cardiovascular diseases. We addressed this issue by performing whole-genome shotgun bisulfite sequencing and high-resolution DNAmethylation array analysis of healthy and diseased donor-matched atherosclerotic DNA methylomes.Overall design: Sequencing of bisulfite converted DNA and array based analysis of atherosclerotic lesions and normal carotid tissue.

Data type: Epigenomics

Sample scope: Multiisolate

Relevance: Medical

Last updated: 2013-04-25