p27 binds to promoters of multiple genes leading to their repression
Source: NCBI BioProject (ID PRJNA129795)
Source: NCBI BioProject (ID PRJNA129795)
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Project name: Mus musculus
Description: The role of the cyclin-cdk inhibitor p27 in tumorigenesis is still a controversial matter. We demonstrate here that p27 negatively regulates transcription of a number of genes (p27-target genes) involved in key cellular functions as RNA processing, translation, respiration and cell proliferation.Overall design: Crosslinked chromatin from quiescent NIH3T3 cells was sonicated, incubated overnight with the rabbit anti-p27 and IgG antibodies as control
Data type: Epigenomics
Sample scope: Multiisolate
Relevance: ModelOrganism
Organization: Cell Biology, Immunology and Neurosciences, University of Barcelona
Release date: 2011-12-01
Last updated: 2010-01-27