Project name: Influenza A virus

Description: The evolution and host adaptation of influenza viruses are facilitated by the highly error-prone replication process catalyzed by the viral RNA-dependent RNA polymerase. However, amino acid residues involved in the fidelity of influenza virus RNA polymerase are still unclear. To elucidate the molecular mechanism of the error-prone replication by the influenza virus RNA polymerase, we try to identify amino acid residues that alter the fidelity of viral polymerase by isolation of nucleotide analog escape mutants.

Data type: Targeted Locus (Loci)

Sample scope: Multispecies

Relevance: Medical

Release date: 2020-04-06

Last updated: 2020-03-30