scRNA-seq of HHEX-Dependent Enterocyte Lineage Commitment in the Drosophila Larval Midgut - Project - Data resources

CNP0007162

scRNA-seq of HHEX-Dependent Enterocyte Lineage Commitment in the Drosophila Larval Midgut
Source: CNGBdb Project (ID CNP0007162)

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Description: While HHEX is an established regulator of endodermal organogenesis, its role in intestinal epithelial dynamics remains unexplored. We developed a Drosophila midgut-specific NP1-Gal4 > UAS-HHEX RNAi model to circumvent mammalian system limitations, enabling precise dissection of HHEX function in vivo. Through single-cell transcriptomics, we generated a comprehensive cellular atlas of Drosophila 3rd instar larval midgut, resolving all major lineages including adult midgut progenitors (AMPs), enteroendocrine cells (EEs), and functionally distinct enterocyte (EC) subtypes defined by metabolic genes.

Data type: Raw sequence reads; Transcriptome or Gene expression

Sample scope: Monoisolate

Submitter: 涂桢铖; 华大基因研究院/华大生命科学研究院（BGI Research）

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