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Description: Organ-selective delivery of messenger RNA (mRNA) is critical for fulfilling the therapeutic potential of mRNA-based gene and protein replacement technologies. Despite clinical advances in hepatic delivery of mRNA using lipid nanoparticles (LNPs), strategies for extrahepatic organ-selective mRNA delivery remain underexplored. Here, we report a strategy, termed peptide-encoded organ-selective targeting (POST), that allows digital programming of LNPs, through surface engineering with specific amino acid sequences (POST codes), to deliver mRNA to extrahepatic organs after systemic administration.
Data type: scRNA-seq
Sample scope: Other
Relevance: Other
Submitter: 王岳(YUE WANG); 北京华大生命科学研究院
Release date: 2025-08-29
Last updated: 2025-08-29
DOI: 10.26036/CNP0006703
Statistics: 1 single cell