The effect of vasopressin V1- and V2-receptor antagonists on hemodynamics in early and late phase after myocardial infarction in rats.
Jpn J Pharmacol, 1998/10;78(2):229-32.
Fujita H[1], Yoshiyama M, Takeuchi K, Omura T, Yamagishi H, Iwao H, Miura K, Yoshikawa J
Affiliations
PMID: 9829627
Abstract
This study was designed to assess the effect of a nonpeptide vasopressin V1-receptor antagonist, OPC-21268, and a vasopressin V2-receptor antagonist, OPC-31260, on hemodynamics in the early phase and the late phase after myocardial infarction in rats. In the early phase, OPC-21268 (30 mg/kg/day) or OPC-31260 (30 mg/kg/day) was orally administered from day 1 to day 5 after the operation; and hemodynamics were measured at day 5, in the late phase from 10 weeks to 11 weeks and measured at the end of 11 weeks. In the early phase, OPC-21268 reduced the left ventricular end-diastolic pressure (LVEDP) concomitantly with the reduction in systemic blood pressure, but did not change LVEDP in the late phase. OPC-31260 reduced LVEDP and central venous pressure in both phases. OPC-21268 improved hemodynamics only in the early phase and OPC-31260 improved it in both phases.
MeSH terms
Administration, Oral; Animals; Antidiuretic Hormone Receptor Antagonists; Benzazepines; Heart Ventricles; Hemodynamics; Male; Myocardial Infarction; Organ Size; Piperidines; Quinolones; Rats; Rats, Wistar; Time Factors; Vasopressins; Ventricular Function, Left
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