Complete genome sequence of Treponema pallidum, the syphilis spirochete.
Science, 1998/7/17;281(5375):375-88.
Fraser CM[1], Norris SJ, Weinstock GM, White O, Sutton GG, Dodson R, Gwinn M, Hickey EK, Clayton R, Ketchum KA, Sodergren E, Hardham JM, McLeod MP, Salzberg S, Peterson J, Khalak H, Richardson D, Howell JK, Chidambaram M, Utterback T, McDonald L, Artiach P, Bowman C, Cotton MD, Fujii C, Garland S, Hatch B, Horst K, Roberts K, Sandusky M, Weidman J, Smith HO, Venter JC
Affiliations
PMID: 9665876
Impact factor: 63.714
Abstract
The complete genome sequence of Treponema pallidum was determined and shown to be 1,138,006 base pairs containing 1041 predicted coding sequences (open reading frames). Systems for DNA replication, transcription, translation, and repair are intact, but catabolic and biosynthetic activities are minimized. The number of identifiable transporters is small, and no phosphoenolpyruvate:phosphotransferase carbohydrate transporters were found. Potential virulence factors include a family of 12 potential membrane proteins and several putative hemolysins. Comparison of the T. pallidum genome sequence with that of another pathogenic spirochete, Borrelia burgdorferi, the agent of Lyme disease, identified unique and common genes and substantiates the considerable diversity observed among pathogenic spirochetes.
MeSH terms
Bacterial Proteins; Base Sequence; Borrelia burgdorferi Group; Carrier Proteins; DNA Repair; DNA Replication; DNA Restriction Enzymes; Energy Metabolism; Genes, Bacterial; Genes, Regulator; Genome, Bacterial; Heat-Shock Response; Lipoproteins; Membrane Proteins; Molecular Sequence Data; Movement; Open Reading Frames; Oxygen Consumption; Protein Biosynthesis; Recombination, Genetic; Replication Origin; Sequence Analysis, DNA; Transcription, Genetic; Treponema pallidum
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