Genetic and environmental contributions to alcohol dependence risk in a national twin sample: consistency of findings in women and men.
Psychol Med, 1997/11;27(6):1381-96.
Heath AC[1], Bucholz KK, Madden PA, Dinwiddie SH, Slutske WS, Bierut LJ, Statham DJ, Dunne MP, Whitfield JB, Martin NG
Affiliations
PMID: 9403910
Impact factor: 10.592
Abstract
background: Genetic influences on alcoholism risk are well-documented in men, but uncertain in women. We tested for gender differences in genetic influences on, and risk-factors for, DSM-III-R alcohol dependence (AD).
method: Diagnostic follow-up interviews were conducted in 1992-3 by telephone with twins from an Australian twin panel first surveyed in 1980-82 (N = 5889 respondents). Data were analysed using logistic regression models.
results: Significantly higher twin pair concordances were observed in MZ compared to DZ same-sex twin pairs in women and men, even when data were weighted to adjust for over-representation of well-educated respondents, and for selective attrition. AD risk was increased in younger birth cohorts, in Catholic males or women reporting no religious affiliation, in those reporting a history of conduct disorder or major depression and in those with high Neuroticism, Social Non-conformity, Toughmindedness, Novelty-Seeking or (in women only) Extraversion scores; and decreased in 'Other Protestants', weekly church attenders, and university-educated males. Controlling for these variables, however, did not remove the significant association with having an alcoholic MZ co-twin, implying that much of the genetic influence on AD risk remained unexplained. No significant gender difference in the genetic variance in AD was found (64% heritability, 95% confidence interval 32-73%).
conclusions: Genetic risk-factors play as important a role in determining AD risk in women as in men. With the exception of certain sociocultural variables such as religious affiliation, the same personality, sociodemographic and axis I correlates of alcoholism risk are observed in women and men.
MeSH terms
Adult; Aged; Aged, 80 and over; Alcoholism; Australia; Catholicism; Diseases in Twins; Female; Humans; Logistic Models; Male; Middle Aged; Models, Genetic; Odds Ratio; Personality; Prevalence; Registries; Risk Factors; Severity of Illness Index; Sex Factors; Twins, Dizygotic; Twins, Monozygotic
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