Transferable cefoxitin resistance in enterobacteria from Greek hospitals and characterization of a plasmid-mediated group 1 beta-lactamase (LAT-2).
Antimicrob Agents Chemother, 1996/7;40(7):1736-40.
Gazouli M[1], Tzouvelekis LS, Prinarakis E, Miriagou V, Tzelepi E
Affiliations
PMID: 8807075
Impact factor: 5.938
Abstract
Cefoxitin resistance in Klebsiella pneumoniae from Escherichia coli strains isolated in Greek hospitals was found to be due to the acquisition of similar plasmids coding for group 1 beta-lactamases. The plasmids were not self-transferable but were mobilized by conjugative plasmids. These elements have also been spread to Enterobacter aerogenes. The most common enzyme was a Citrobacter freundii-derived cephalosporinase (LAT-2) which differed from LAT-1 by three amino acids.
MeSH terms
Amino Acid Sequence; Base Sequence; Cefoxitin; Cephamycins; Citrobacter freundii; Conjugation, Genetic; Cross Infection; Drug Resistance, Microbial; Enterobacter; Enterobacteriaceae; Escherichia coli; Greece; Microbial Sensitivity Tests; Molecular Sequence Data; Penicillinase; Plasmids
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