Studies on the synthesis and antidepressant activity of some 1-thiocarbamoyl-3,5-diphenyl-2-pyrazolines.
Arzneimittelforschung, 1993/10;43(10):1041-4.
Bilgin AA[1], Palaska E, Sunal R
Affiliations
PMID: 8267665
Abstract
Several 1-thiocarbamoyl-3,5-diphenyl-2-pyrazoline derivatives have been synthesized by reacting 1,3-diphenyl-2-propen-1-one (chalcones) with thiosemicarbazide, or hydrazine hydrate and then with various isothiocyanates. Their chemical structures have been proven by UV, IR, 1H-NMR and elemental analysis. Antidepressant activities were investigated by "Porsolt's Behavioural Despair Test". 1-Thiocarbamoyl-3-(phenyl and 4-chlorophenyl-5-(4-methyl and 4-methoxyphenyl-2-pyrazoline (compounds III, IV, VII, VIII) and 3-(4-methylphenyl)-5-(4-methoxyphenyl)-2-pyrazoline (compound XII) showed equivalent or higher activity than pargyline hydrochloride and tranylcypromine sulfate.
MeSH terms
Animals; Antidepressive Agents; Drug Evaluation, Preclinical; Magnetic Resonance Spectroscopy; Male; Mice; Pargyline; Pyrazoles; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Swimming; Tranylcypromine
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