Augmentation of host resistance against bacterial infection by treatment with leustroducsin B, a new CSF inducer.
Microbiol Immunol, 1994;38(9):741-5.
Kohama T[1], Katayama T, Inukai M, Maeda H, Shiraishi A
Affiliations
PMID: 7854215
Impact factor: 2.962
Abstract
We tested the in vivo activity of leustroducsin B (LSN B), a new colony-stimulating factor (CSF) inducer isolated from the culture broth of Streptomyces platensis, with mice infected with Escherichia coli. Treatment with LSN B augmented the host resistance to lethal infection of E. coli at doses between 0.1 mg/kg and 1 mg/kg. Serum interleukin-6 (IL-6) levels were found to increase after this treatment, and superoxide anion generation of neutrophils was enhanced in vivo, suggesting that LSN B augmented the host resistance at least in part by inducing IL-6, which subsequently enhanced the bactericidal activity of the neutrophils.
MeSH terms
Animals; Anti-Bacterial Agents; Colony-Stimulating Factors; Enzyme-Linked Immunosorbent Assay; Escherichia coli Infections; Immunity; Interleukin-6; Lactones; Male; Mice; Mice, Inbred ICR; Neutrophils; Organophosphorus Compounds; Pyrones; Superoxides
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