The effect of beta-receptor stimulation on the activity of the inhibitor of cAMP-dependent protein kinase.
Acta Physiol Pol, 1981/9-1981/10;32(5):501-6.
PMID: 6121459
Abstract
Isoprenaline and adrenaline produced an increase of cAMP content and a decrease of the activity of the endogenous inhibitor of cAMP-dependent protein kinase (type I inhibitor) in human lymphocytes and in rat heart. The maximal effect was seen at a concentration of 10(-6) M. Noradrenaline and dopamine required much higher concentration to elicite the same effect. The decrease of type I inhibitor activity was mediated through beta-adrenergic receptors because propranolol, but not phentolamine, blocked the effects produced by isoprenaline. Stimulation of beta-adrenergic receptors did not influence the activity of type II inhibitor.
MeSH terms
Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Carrier Proteins; Cyclic AMP; Ethanolamines; Intracellular Signaling Peptides and Proteins; Isoproterenol; Lymphocytes; Myocardium; Phentolamine; Propranolol; Rats; Receptors, Adrenergic, beta
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