Pharmacokinetics of fenfluramine enantiomers in man.
Eur J Drug Metab Pharmacokinet, 1979;4(3):129-32.
Caccia S, Ballabio M, De Ponte P
PMID: 527596
Impact factor: 2.569
Abstract
The pharmacokinetics of fenfluramine enantiomers were studied in normal volunteers following the administration of single of multiple doses of racemic fenfluramine hydrochloride. Plasma concentrations and half-lives were similar for both enantiomers after single 40 mg of 60 mg doses. However following chronic administration (2 x 40 mg for 10 days), significant differences were observed between the kinetic parameters of the two enantiomers, the l-form of fenfluramine and norfenfluramine accumulating in plasms more than the d-forms.
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