TRMT6/TRMT61A-mediated tRNA m1A modification enhances protein translation and activates the IRE1α-XBP1s pathway to promote anaplastic thyroid cancer progression.
Cell Mol Biol Lett , 2026/2/10;
Ding Y [1 , 2 , Feng Z [2 , 3 , Chen G [3 ] , Liu Y [3 ] , Zhu Y [3 ] , Cao K [4 ]
Affiliations
Department of Breast Thyroid Surgery, Third Xiangya Hospital, Central South University, Changsha, 410013, Hunan, China. Postdoctoral Station of Medical Aspects of Specific Environments, the Third Xiangya Hospital, Central South University, Changsha, China. Department of Oncology, Third Xiangya Hospital, Central South University, Changsha, 410013, Hunan, China. Department of Oncology, Third Xiangya Hospital, Central South University, Changsha, 410013, Hunan, China. csucaoke@163.com. PMID: 41667948 DOI: 10.1186/s11658-026-00863-6
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Keywords: IRE1α–XBP1s; TRMT6/TRMT61A; Translation; m1A modification; tRNA
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