Synthetic Modifications of Andrographolide Targeting New Potential Anticancer Drug Candidates: A Comprehensive Overview.
Molecules, 2024/6/18;29(12)
Messire G[1], Rollin P[1], Gillaizeau I[1], Berteina-Raboin S[1]
Affiliations
PMID: 38930949DOI: 10.3390/molecules29122884
Impact factor: 4.927
Abstract
This review collects the synthetic modifications performed on andrographolide, a natural molecule derived from Andrographis paniculata, for oncology applications. Various pharmacomodulations were carried out, and the products were tested on different cancer cell lines. The impact of these modifications was analyzed with the aim of mapping the positions essential for activity to facilitate future research in this field. However, this study makes it clear that, in addition to structural modifications of the molecule, which can result in varying degrees of effectiveness in targeting interactions, the lipophilic capacity of the structures obtained through hemisynthesis is of significant importance.
Keywords: Andrographis paniculata; andrographolide; drug candidates; oncology; synthetic modifications
MeSH terms
Diterpenes; Humans; Antineoplastic Agents; Structure-Activity Relationship; Neoplasms; Andrographis; Cell Line, Tumor; Molecular Structure; Animals
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