A lineage-specific Exo70 is required for receptor kinase-mediated immunity in barley.
Sci Adv, 2022/7/08;8(27):eabn7258.
Holden S[1], Bergum M[1], Green P[1], Bettgenhaeuser J[1], Hernández-Pinzón I[1], Thind A[1], Clare S[1], Russell JM[1], Hubbard A[2], Taylor J[1], Smoker M[1], Gardiner M[1], Civolani L[1, 3], Cosenza F[1, 3], Rosignoli S[3], Strugala R[4], Molnár I[5], Šimková H[5], Doležel J[5], Schaffrath U[4], Barrett M[6], Salvi S[3], Moscou MJ[1]
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PMID: 35857460DOI: 10.1126/sciadv.abn7258
Impact factor: 14.957
Abstract
In the evolution of land plants, the plant immune system has experienced expansion in immune receptor and signaling pathways. Lineage-specific expansions have been observed in diverse gene families that are potentially involved in immunity but lack causal association. Here, we show that Rps8-mediated resistance in barley to the pathogen Puccinia striiformis f. sp. tritici (wheat stripe rust) is conferred by a genetic module: Pur1 and Exo70FX12, which are together necessary and sufficient. Pur1 encodes a leucine-rich repeat receptor kinase and is the ortholog of rice Xa21, and Exo70FX12 belongs to the Poales-specific Exo70FX clade. The Exo70FX clade emerged after the divergence of the Bromeliaceae and Poaceae and comprises from 2 to 75 members in sequenced grasses. These results demonstrate the requirement of a lineage-specific Exo70FX12 in Pur1-mediated immunity and suggest that the Exo70FX clade may have evolved a specialized role in receptor kinase signaling.
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