Epigenetic mapping of the somatotropic axis in Nile tilapia reveals differential DNA hydroxymethylation marks associated with growth.
Genomics, 2021/09;113(5):2953-2964.
Konstantinidis I[1], Anastasiadi D[2], Sætrom P[3], Nedoluzhko AV[1], Mjelle R[4], Podgorniak T[1], Piferrer F[5], Fernandes JMO[6]
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PMID: 34214627DOI: 10.1016/j.ygeno.2021.06.037
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Abstract
In vertebrates, the somatotropic axis comprising the pituitary gland, liver and muscle plays a major role in myogenesis. Its output in terms of muscle growth is highly affected by nutritional and environmental cues, and thus likely epigenetically regulated. Hydroxymethylation is emerging as a DNA modification that modulates gene expression but a holistic characterization of the hydroxymethylome of the somatotropic axis has not been investigated to date. Using reduced representation 5-hydroxymethylcytosine profiling we demonstrate tissue-specific localization of 5-hydroxymethylcytosines at single nucleotide resolution. Their abundance within gene bodies and promoters of several growth-related genes supports their pertinent role in gene regulation. We propose that cytosine hydroxymethylation may contribute to the phenotypic plasticity of growth through epigenetic regulation of the somatotropic axis.
Keywords: DNA hydroxymethylation; Epigenetics; Growth; Somatotropic axis; Teleosts
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