Phialemoniopsis limonesiae sp. nov. causing cutaneous phaeohyphomycosis in an immunosuppressed woman.
Emerg Microbes Infect, 2021/12;10(1):400-406.
Alvarez Martinez D[1], Alberto C[1], Riat A[2], Schuhler C[1], Valladares P[3], Ninet B[4], Kraak B[5], Crous PW[5], Hou LW[6], Toutous Trellu L[1]
Affiliations
PMID: 33634736DOI: 10.1080/22221751.2021.1892458
Impact factor: 19.568
Abstract
Rare or opportunistic fungal infections are mostly described in immunosuppressed patients. We present a case of a cutaneous phaeohyphomycosis that developed on the dorsal foot in an immunosuppressed woman suffering from AIDS, caused by a novel Phialemoniopsis species. It clinically presented as an indurated violaceous plaque, surmounted by nodules exuding a sero-purulent discharge. A filamentous fungus was isolated from pus and cutaneous biopsy. ITS and LSU sequences phylogenetically resolved the fungus as an unknown species of Phialemoniopsis, which is an unresolved family within Sordariomycetes. In this study we describe the new species as Phialemoniopsis limonesiae, which clusters on a single branch clearly separated from its closest phylogenetic neighbours. This new strain showed low MIC to itraconazole, voriconazole and posaconazole.
Keywords: Bioavailability itraconazole; a new taxon; deep cutaneous phaeohyphomycosis; immunosuppression; opportunistic fungal infections
MeSH terms
Anti-Bacterial Agents; DNA, Fungal; Female; Foot; Humans; Immunocompromised Host; Middle Aged; Opportunistic Infections; Phaeohyphomycosis; Saccharomycetales; Sequence Analysis, DNA
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