Genome sequencing of deep-sea hydrothermal vent snails reveals adaptions to extreme environments.
Gigascience, 2020/12/15;9(12)
Zeng X[1], Zhang Y[2, 3, 4], Meng L[2], Fan G[2, 3, 5], Bai J[3], Chen J[2], Song Y[2], Seim I[6, 7], Wang C[2], Shao Z[2], Liu N[3], Lu H[3], Fu X[1], Wang L[1], Liu X[2, 3, 8], Liu S[2], Shao Z[1]
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PMID: 33319911DOI: 10.1093/gigascience/giaa139
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Abstract
background: The scaly-foot snail (Chrysomallon squamiferum) is highly adapted to deep-sea hydrothermal vents and has drawn much interest since its discovery. However, the limited information on its genome has impeded further related research and understanding of its adaptation to deep-sea hydrothermal vents.
findings: Here, we report the whole-genome sequencing and assembly of the scaly-foot snail and another snail (Gigantopelta aegis), which inhabits similar environments. Using Oxford Nanopore Technology, 10X Genomics, and Hi-C technologies, we obtained a chromosome-level genome of C. squamiferum with an N50 size of 20.71 Mb. By constructing a phylogenetic tree, we found that these 2 deep-sea snails evolved independently of other snails. Their divergence from each other occurred ∼66.3 million years ago. Comparative genomic analysis showed that different snails have diverse genome sizes and repeat contents. Deep-sea snails have more DNA transposons and long terminal repeats but fewer long interspersed nuclear elements than other snails. Gene family analysis revealed that deep-sea snails experienced stronger selective pressures than freshwater snails, and gene families related to the nervous system, immune system, metabolism, DNA stability, antioxidation, and biomineralization were significantly expanded in scaly-foot snails. We also found 251 H-2 Class II histocompatibility antigen, A-U α chain-like (H2-Aal) genes, which exist uniquely in the Gigantopelta aegis genome. This finding is important for investigating the evolution of major histocompatibility complex (MHC) genes.
conclusion: Our study provides new insights into deep-sea snail genomes and valuable resources for further studies.
Keywords: biomineralization; comparative genomics; deep-sea snails; genome assembly
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