A multiple drug-resistant Streptococcus pneumoniae of serotype 15A occurring from serotype 19A by capsular switching.
Vaccine, 2020/07/14;38(33):5114-5118.
Savinova T[1], Brzhozovskaya E[2], Shagin D[3], Mikhaylova Y[4], Shelenkov A[4], Yanushevich Y[4], Mayanskiy N[5]
Affiliations
PMID: 32565342DOI: 10.1016/j.vaccine.2020.05.075
Impact factor: 4.169
Abstract
Streptococcus pneumoniae is a highly recombinogenic pathogen. The ability of pneumococci to acquire and incorporate exogenous DNA is an important evolutionary mechanism for adaptation to clinical interventions such as antibiotic therapy and vaccination. Herein, using whole genome sequencing we detected a multiple drug-resistant serotype 15A pneumococcus emerged by capsular switching from serotype 19A/ST276. The dissemination of recombinant multiple drug-resistant pneumococcal clones with non-vaccine type capsule is of concern and warrants thorough monitoring of serotype and genotype structure within pneumococcal populations.
Keywords: Capsular switching; Multiple drug-resistant pneumococcus; Serotype 15A; Streptococcus pneumoniae
MeSH terms
Anti-Bacterial Agents; Humans; Microbial Sensitivity Tests; Pharmaceutical Preparations; Pneumococcal Infections; Pneumococcal Vaccines; Serogroup; Serotyping; Streptococcus pneumoniae; Whole Genome Sequencing
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