Suzuki-Miyaura cross coupling is not an informative reaction to demonstrate the performance of new solvents.
Beilstein J Org Chem, 2020;16:1001-1005.
Sherwood J[1]
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PMID: 32509031DOI: 10.3762/bjoc.16.89
Impact factor: 2.544
Abstract
The development and study of new solvents has become important due to a proliferation of regulations preventing or limiting the use of many conventional solvents. In this work, the suitability of the Suzuki-Miyaura reaction to demonstrate the usefulness of new solvents was evaluated, including Cyrene™, dimethyl isosorbide, ethyl lactate, 2-methyltetrahydrofuran (2-MeTHF), propylene carbonate, and γ-valerolactone (GVL). It was found that the cross coupling is often unaffected by the choice of solvent, and therefore the Suzuki-Miyaura reaction provides limited information regarding the usefulness of any particular solvent for organic synthesis.
Keywords: Suzuki reaction; cross coupling; green solvents; palladium; solvent selection
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