The Effectiveness of Potential Probiotics Lactobacillus rhamnosus Vahe and Lactobacillus delbrueckii IAHAHI in Irradiated Rats Depends on the Nutritional Stage of the Host.
Probiotics Antimicrob Proteins, 2020/12;12(4):1439-1450.
Pepoyan AZ[1, 2], Manvelyan AM[3], Balayan MH[3], McCabe G[4], Tsaturyan VV[5, 6], Melnikov VG[7], Chikindas ML[8, 9], Weeks R[8], Karlyshev AV[4]
Affiliations
PMID: 32462507DOI: 10.1007/s12602-020-09662-7
Impact factor: 5.265
Abstract
Several species of eukaryotic organisms living in the high mountain areas of Armenia with naturally occurring levels of radiation have high adaptive responses to radiation. We speculate on the role of the gastrointestinal microbiota in this protection against radiation. Therefore, seventeen microorganisms with high antagonistic activities against several multi-drug-resistant pathogens were isolated from the human and animal gut microbiota, as well as from traditional Armenian fermented products. These strains were tested in vivo on Wistar rats to determine their ability to protect the eukaryotic host against radiation damages. The efficiency of the probiotics' application and the dependence on pre- and post-radiation nutrition of rats were described. The effects of Lactobacillus rhamnosus Vahe, isolated from a healthy breastfed infant, and Lactobacillus delbrueckii IAHAHI, isolated from the fermented dairy product matsuni, on the survival of irradiated rats, and their blood leucocyte and glucose levels, were considered to be the most promising, based on this study's results.
Keywords: Blood glucose level; Pre- and post-radiation effects; Probiotic; Radiation damages; Vitamins; X-ray irradiation
MeSH terms
Animals; Biotin; Cultured Milk Products; Folic Acid; Gastrointestinal Microbiome; Humans; Lactobacillus delbrueckii; Lactobacillus rhamnosus; Leukocyte Count; Male; Nutritional Status; Probiotics; Radiation Dosage; Radiation Injuries; Radiation Tolerance; Radiometry; Rats; Rats, Wistar; Riboflavin; Survival Analysis; Vitamin B 6; Whole-Body Irradiation; X-Rays
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