Fabrication of a novel partially dissolving polymer microneedle patch for transdermal drug delivery.
J Mater Chem B, 2015/1/14;3(2):276-285.
Lee IC [1], He JS , Tsai MT , Lin KC
Affiliations
PMID: 32261948DOI: 10.1039/c4tb01555j
Impact factor: 7.571
Abstract
Polymer microneedles (MNs) have gained increasing attention as a minimally invasive method for efficiently delivering drugs and vaccines in a patient-friendly manner. Herein, an easy and mild process with O2 plasma treatment was used to fabricate polyvinylpyrrolidone (PVP)-polyvinyl alcohol (PVA) MN patches, and efficient, sustained transdermal delivery was achieved. The diffusion rate of the entrained molecules could be controlled by adjusting the ratio of PVP-PVA. Optical coherence tomography was used to monitor the in vitro penetration in real time and to measure the penetration depth. Rhodamine 6G and fluorescein isothiocyanate-labeled bovine serum albumin (BSA-FITC) were used to explore the potential for using partially dissolving MNs as a transdermal delivery device. Confocal microscopy images revealed that the model drug can gradually diffuse from the puncture sites to a deeper depth. The drug-release profile also demonstrated that the PVP-PVA MNs can provide a successful and sustained release and that the transdermal delivery rate was regulated by the PVP-PVA ratio. Furthermore, the two-stage processing strategy developed in this study provides a simple and easy method for localizing the drug in the needle. The partially dissolving MNs developed in this study may serve as a promising device for controlled drug release and for biological storage applications.
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