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32015507
A pneumonia outbreak associated with a new coronavirus of probable bat origin.

Nature, 2020/3;579(7798):270-273.

Zhou P[1], Yang XL[1], Wang XG[2], Hu B[1], Zhang L[1], Zhang W[1], Si HR[1, 3], Zhu Y[1], Li B[1], Huang CL[2], Chen HD[2], Chen J[1, 3], Luo Y[1, 3], Guo H[1, 3], Jiang RD[1, 3], Liu MQ[1, 3], Chen Y[1, 3], Shen XR[1, 3], Wang X[1, 3], Zheng XS[1, 3], Zhao K[1, 3], Chen QJ[1], Deng F[1], Liu LL[4], Yan B[1], Zhan FX[4], Wang YY[1], Xiao GF[1], Shi ZL[5]

Affiliations

PMID: 32015507DOI: 10.1038/s41586-020-2012-7

Impact factor: 69.504

Abstract
Since the outbreak of severe acute respiratory syndrome (SARS) 18 years ago, a large number of SARS-related coronaviruses (SARSr-CoVs) have been discovered in their natural reservoir host, bats1-4. Previous studies have shown that some bat SARSr-CoVs have the potential to infect humans5-7. Here we report the identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China. The epidemic, which started on 12 December 2019, had caused 2,794 laboratory-confirmed infections including 80 deaths by 26 January 2020. Full-length genome sequences were obtained from five patients at an early stage of the outbreak. The sequences are almost identical and share 79.6% sequence identity to SARS-CoV. Furthermore, we show that 2019-nCoV is 96% identical at the whole-genome level to a bat coronavirus. Pairwise protein sequence analysis of seven conserved non-structural proteins domains show that this virus belongs to the species of SARSr-CoV. In addition, 2019-nCoV virus isolated from the bronchoalveolar lavage fluid of a critically ill patient could be neutralized by sera from several patients. Notably, we confirmed that 2019-nCoV uses the same cell entry receptor-angiotensin converting enzyme II (ACE2)-as SARS-CoV.
MeSH terms
Angiotensin-Converting Enzyme 2; Animals; Antibodies, Viral; Betacoronavirus; COVID-19; Cell Line; China; Chiroptera; Chlorocebus aethiops; Coronavirus Infections; Disease Outbreaks; Female; Genome, Viral; Humans; Male; Peptidyl-Dipeptidase A; Phylogeny; Pneumonia, Viral; Severe acute respiratory syndrome-related coronavirus; SARS-CoV-2; Sequence Homology, Nucleic Acid; Severe Acute Respiratory Syndrome; Vero Cells
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