Altered respiratory virome and serum cytokine profile associated with recurrent respiratory tract infections in children.
Nat Commun, 2019/05/23;10(1):2288.
Li Y[1, 2], Fu X[2], Ma J[3], Zhang J[1], Hu Y[2], Dong W[4], Wan Z[5], Li Q[3], Kuang YQ[6], Lan K[2, 7], Jin X[2], Wang JH[8], Zhang C[9, 10]
Affiliations
PMID: 31123265DOI: 10.1038/s41467-019-10294-x
Impact factor: 17.694
Abstract
Recurrent acute respiratory tract infections (ARTIs) affect a large population, yet the specific decisive factors are largely unknown. Here we study a population of 4407 children diagnosed with ARTI, comparing respiratory virome and serum cytokine profiles associated with multiple ARTIs and single ARTI during a six-year period. The relative abundance of Propionibacterium phages is significantly elevated in multiple ARTIs compared to single ARTI group. Serum levels of TIMP-1 and PDGF-BB are markedly increased in multiple ARTIs compared to single-ARTI and non-ARTI controls, making these two cytokines potential predictors for multiple ARTIs. The presence of Propionibacterium phages is associated with higher levels of TIMP-1 and PDGF-BB. Receiver operating characteristic (ROC) curve analyses show that the combination of TIMP-1, PDGF-BB and Propionibacterium phages could be a strong predictor for multiple ARTIs. These findings indicate that respiratory microbe homeostasis and specific cytokines are associated with the onset of multiple ARTIs over time.
MeSH terms
Acute Disease; Bacteriophages; Child; Child, Preschool; Cytokines; Disease Susceptibility; Female; High-Throughput Nucleotide Sequencing; Humans; Infant; Longitudinal Studies; Male; Metagenomics; Microbiota; Propionibacterium; Proteomics; Recurrence; Respiratory System; Respiratory Tract Infections; Retrospective Studies
More resources
Full text:
Europe PubMed Central; PubMed Central
EndNote: Download