Hormonal regulation of benzo[a]pyrene metabolism in human adrenocortical cell cultures.
Biochem Biophys Res Commun, 1985/8/30;131(1):167-73.
Hornsby PJ, Harris SE, Aldern KA
PMID: 2994646
Impact factor: 3.322
Abstract
In cultured fetal human adrenocortical cells, metabolism of the carcinogen benzo[a]pyrene was found to be unresponsive to the xenobiotic inducers 3-methylcholanthrene, benz[a]anthracene and 2,3,7,8-tetrachlorodibenzo-p-dioxin. However, exposure of cultures to the hormone adrenocorticotropin (ACTH) for 48 hours stimulated benzo[a]pyrene metabolism 3-fold. The major metabolite was the 7,8-diol. Other compounds which stimulate the production of adrenocortical cell cyclic AMP (forskolin and cholera toxin) as well as monobutyryl cyclic AMP also increased benzo[a]pyrene metabolism. Human adrenocortical cells thus provide an unusual example of hormonal regulation of the metabolism of a carcinogen.
MeSH terms
Adrenal Cortex; Adrenocorticotropic Hormone; Benzo(a)pyrene; Bucladesine; Carcinogens; Cells, Cultured; Cholera Toxin; Colforsin; Cyclic AMP; Diterpenes; Embryo, Mammalian; Humans; Kinetics
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