Maternal methylmercury from a wild-caught walleye diet induces developmental abnormalities in zebrafish.
Reprod Toxicol, 2016/10;65:272-282.
Liu Q[1], Klingler RH[1], Wimpee B[1], Dellinger M[1], King-Heiden T[1], Grzybowski J[1], Gerstenberger SL[2], Weber DN[1], Carvan MJ 3rd[3]
Affiliations
PMID: 27544571DOI: 10.1016/j.reprotox.2016.08.010
Impact factor: 3.421
Abstract
Maternal methylmercury (MeHg) exposure from a contaminated diet causes adverse effects in offspring, but the underlying mechanism(s) remains unclear. In the present study, we investigated the effects of maternal dietary MeHg-exposure on the offspring, using the zebrafish (Danio rerio) as a model system. Female zebrafish were exposed to MeHg (0.88-3.10ppm) by consuming a diet made from wild-caught walleye originally intended for human consumption. While dietary MeHg exposure did not significantly influence fecundity, offspring showed increases in morphologic alterations and mortality, neurobehavioral dysfunction, and dysregulation of global gene expression. Gene expression analysis suggested that MeHg might affect neuronal and muscular development via dysregulation of genes related to transcriptional regulation (such as supt5h) and cell cycle (such as ccnb1). Results from this study provide evidence that food intended for human consumption, with relatively modest levels of MeHg, may induce adverse effects in offspring.
Keywords: Maternal exposure; MeHg; Offspring; Toxicity; Zebrafish
MeSH terms
Animals; Diet; Embryo, Nonmammalian; Female; Food Contamination; Male; Maternal Exposure; Methylmercury Compounds; Oligonucleotide Array Sequence Analysis; Transcriptome; Vision Disorders; Water Pollutants, Chemical; Zebrafish
More resources
EndNote: Download