Lignans from the roots of Acorus tatarinowii Schott ameliorate β amyloid-induced toxicity in transgenic Caenorhabditis elegans.
Fitoterapia, 2016/1;108:5-8.
Luo XH[1], Zhang YY[1], Chen XY[1], Sun ML[1], Li S[1], Wang HB[2]
Affiliations
PMID: 26586617
Impact factor: 3.204
Abstract
A novel tetralignan, tatarinan T (1) with the rare C8-C7' linkage pattern, along with a known monolignan (2) were isolated from the roots of Acorus tatarinowii Schott. Their chemical structures were elucidated on the basis of NMR and X-ray diffraction analysis. We evaluated the protective effects of two rare lignans against β-amyloid toxicity by using CL4176 transgenic C. elegans model for the first time, and found that they significantly delayed paralysis of worms at the concentration of 100 μM. Compound 2 exhibited the more potential protective effect against β-amyloid toxicity, its value of PT50 extended up to 62.3% at 100 μM compared with control, especially, it still has 30.8% extension at 10 μM.
Keywords: Acorus tatarinowii; C. elegans; Lignan; Paralysis
MeSH terms
Acorus; Amyloid beta-Peptides; Animals; Animals, Genetically Modified; Caenorhabditis elegans; Drugs, Chinese Herbal; Lignans; Molecular Structure; Plant Extracts; Plant Roots
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