Fonsecaea pugnacius, a Novel Agent of Disseminated Chromoblastomycosis.
J Clin Microbiol, 2015/8;53(8):2674-85.
de Azevedo CM[1], Gomes RR[2], Vicente VA[3], Santos DW[4], Marques SG[5], do Nascimento MM[2], Andrade CE[2], Silva RR[1], Queiroz-Telles F[6], de Hoog GS[7]
Affiliations
PMID: 26085610DOI: 10.1128/JCM.00637-15
Impact factor: 11.677
Abstract
We report a fatal case of a chromoblastomycosis-like infection caused by a novel species of Fonsecaea in a 52-year-old immunocompetent Caucasian male from an area of chromoblastomycosis endemicity in Brazil. The patient had a 30-year history of slowly evolving, verrucous lesions on the right upper arm which gradually affected the entire arm, the left hemifacial area, and the nose. Subsequent dissemination to the brain was observed, which led to death of the patient. The internal transcribed spacer (ITS) and partial large subunit (LSU), BT2, and CDC42 genes of the isolates recovered from skin and brain were sequenced, confirming the novelty of the species. The species is clinically unique in causing brain abscesses secondary to chromoblastomycosis lesions despite the apparent intact immunity of the patient. Histopathologic appearances were very different, showing muriform cells in skin and hyphae in brain.
MeSH terms
Ascomycota; Brain; Brazil; Chromoblastomycosis; Cluster Analysis; DNA, Fungal; DNA, Ribosomal; DNA, Ribosomal Spacer; Fatal Outcome; Head; Histocytochemistry; Humans; Magnetic Resonance Imaging; Male; Microscopy; Middle Aged; Molecular Sequence Data; Phylogeny; RNA, Ribosomal; Radiography; Sequence Analysis, DNA; Skin; Whites
More resources
Full text:
Europe PubMed Central; PubMed Central
EndNote: Download