Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.
EMBO Rep, 2014/8;15(8):894-902.
Anver S[1], Roguev A[2], Zofall M[3], Krogan NJ[2], Grewal SI[3], Harmer SL[4]
Affiliations
PMID: 24957674DOI: 10.15252/embr.201438902
Impact factor: 9.071
Abstract
Chromatin regulatory proteins affect diverse developmental and environmental response pathways via their influence on nuclear processes such as the regulation of gene expression. Through a genome-wide genetic screen, we implicate a novel protein called X-chromosome-associated protein 5 (Xap5) in chromatin regulation. We show that Xap5 is a chromatin-associated protein acting in a similar manner as the histone variant H2A.Z to suppress expression of antisense and repeat element transcripts throughout the fission yeast genome. Xap5 is highly conserved across eukaryotes, and a plant homolog rescues xap5 mutant yeast. We propose that Xap5 likely functions as a chromatin regulator in diverse organisms.
Keywords: aberrant transcripts; chromatin modification; long terminal repeats; transcriptional repression; transposable elements
MeSH terms
Antisense Elements (Genetics); Arabidopsis; Arabidopsis Proteins; DNA-Binding Proteins; Genes, Fungal; Genetic Complementation Test; Histones; Protein Binding; RNA, Fungal; RNA, Messenger; Repetitive Sequences, Nucleic Acid; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Transcription, Genetic; Up-Regulation
More resources
Full text:
Europe PubMed Central; PubMed Central
EndNote: Download