Genome and transcriptome of the porcine whipworm Trichuris suis.
Nat Genet, 2014/7;46(7):701-6.
Jex AR[1], Nejsum P[2], Schwarz EM[3], Hu L[4], Young ND[1], Hall RS[1], Korhonen PK[1], Liao S[4], Thamsborg S[2], Xia J[4], Xu P[4], Wang S[4], Scheerlinck JP[1], Hofmann A[5], Sternberg PW[6], Wang J[7], Gasser RB[1]
Affiliations
PMID: 24929829DOI: 10.1038/ng.3012
Impact factor: 41.307
Abstract
Trichuris (whipworm) infects 1 billion people worldwide and causes a disease (trichuriasis) that results in major socioeconomic losses in both humans and pigs. Trichuriasis relates to an inflammation of the large intestine manifested in bloody diarrhea, and chronic disease can cause malnourishment and stunting in children. Paradoxically, Trichuris of pigs has shown substantial promise as a treatment for human autoimmune disorders, including inflammatory bowel disease (IBD) and multiple sclerosis. Here we report whole-genome sequencing at ∼140-fold coverage of adult male and female T. suis and ∼80-Mb draft assemblies. We explore stage-, sex- and tissue-specific transcription of mRNAs and small noncoding RNAs.
MeSH terms
Animals; Female; Gene Expression Profiling; Gene Regulatory Networks; Genome, Helminth; High-Throughput Nucleotide Sequencing; Host-Parasite Interactions; Humans; Male; Swine; Trichuriasis; Trichuris
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