Complete nucleotide sequence of two multidrug-resistant IncR plasmids from Klebsiella pneumoniae.
Antimicrob Agents Chemother, 2014/7;58(7):4207-10.
Compain F[1], Frangeul L[2], Drieux L[3], Verdet C[4], Brisse S[5], Arlet G[6], Decré D[7]
Affiliations
PMID: 24752259DOI: 10.1128/AAC.02773-13
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Abstract
We report here the complete nucleotide sequence of two IncR replicons encoding multidrug resistance determinants, including β-lactam (blaDHA-1, blaSHV-12), aminoglycoside (aphA1, strA, strB), and fluoroquinolone (qnrB4, aac6'-1b-cr) resistance genes. The plasmids have backbones that are similar to each other, including the replication and stability systems, and contain a wide variety of transposable elements carrying known antibiotic resistance genes. This study confirms the increasing clinical importance of IncR replicons as resistance gene carriers.
MeSH terms
Aminoglycosides; Anti-Bacterial Agents; Base Sequence; DNA Transposable Elements; Drug Resistance, Multiple, Bacterial; Fluoroquinolones; Genes, MDR; Klebsiella pneumoniae; Microbial Sensitivity Tests; Molecular Sequence Data; R Factors; Sequence Analysis, DNA; beta-Lactam Resistance; beta-Lactamases
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