A novel cell death gene acts to repair patterning defects in Drosophila melanogaster.
Genetics, 2014/6;197(2):739-42.
Tanaka KM[1], Takahashi A[2], Fuse N[3], Takano-Shimizu-Kouno T[4]
Affiliations
PMID: 24671768DOI: 10.1534/genetics.114.163337
Impact factor: 4.402
Abstract
Cell death is a mechanism utilized by organisms to eliminate excess cells during development. Here, we describe a novel regulator of caspase-independent cell death, Mabiki (Mabi), that is involved in the repair of the head patterning defects caused by extra copies of bicoid in Drosophila melanogaster. Mabiki functions together with caspase-dependent cell death mechanisms to provide robustness during development.
Keywords: Drosophila melanogaster; bicoid; developmental robustness; embryogenesis; p35-insensitive cell death
MeSH terms
Animals; Body Patterning; Cell Death; Drosophila Proteins; Drosophila melanogaster; Gene Expression Regulation, Developmental; Gene Knockdown Techniques; Head
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