Molecular rules governing de novo methylation in cancer.
Cancer Res, 2014/3/01;74(5):1475-83.
Nejman D[1], Straussman R, Steinfeld I, Ruvolo M, Roberts D, Yakhini Z, Cedar H
Affiliations
PMID: 24453003DOI: 10.1158/0008-5472.CAN-13-3042
Impact factor: 13.312
Abstract
De novo methylation of CpG islands is seen in many cancers, but the general rules governing this process are not known. By analyzing DNA from tumors, as well as normal tissues, and by utilizing a range of published data, we have identified a universal set of tumor targets, each with its own "coefficient" of methylation that is largely correlated with its inherent relative ability to recruit polycomb. This pattern is initially formed by a slow process of de novo methylation that occurs during aging and then undergoes expansion early in tumorigenesis, where we hypothesize that it may act as an inhibitor of development-associated gene activation.
MeSH terms
More resources
EndNote: Download