The complete nucleotide sequence of the carbapenem resistance-conferring conjugative plasmid pLD209 from a Pseudomonas putida clinical strain reveals a chimeric design formed by modules derived from both environmental and clinical bacteria.
Antimicrob Agents Chemother, 2014;58(3):1816-21.
Marchiaro PM[1], Brambilla L, Morán-Barrio J, Revale S, Pasteran F, Vila AJ, Viale AM, Limansky AS
Affiliations
PMID: 24395220DOI: 10.1128/AAC.02494-13
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Abstract
The complete sequence of the carbapenem-resistance-conferring conjugative plasmid pLD209 from a Pseudomonas putida clinical strain is presented. pLD209 is formed by 3 well-defined regions: an adaptability module encompassing a Tn402-like class 1 integron of clinical origin containing blaVIM-2 and aacA4 gene cassettes, partitioning and transfer modules, and a replication module derived from plasmids of environmental bacteria. pLD209 is thus a mosaic of modules originating in both the clinical and environmental (nonclinical) microbiota.
MeSH terms
Base Sequence; Carbapenems; Conjugation, Genetic; Genes, Bacterial; Molecular Sequence Data; Open Reading Frames; Pseudomonas putida; R Factors; beta-Lactam Resistance
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