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24123634
Thiols and selenols as electron-relay catalysts for disulfide-bond reduction.

Angew Chem Int Ed Engl, 2013/12/02;52(49):12901-4.

Lukesh JC 3rd[1], Vanveller B, Raines RT

Affiliations

PMID: 24123634DOI: 10.1002/anie.201307481

Impact factor: 16.823

Abstract
Pass them on! Dithiobutylamine immobilized on a resin is a useful reagent for the reduction of disulfide bonds. Its ability to reduce a disulfide bond in a protein is enhanced greatly if used along with a soluble strained cyclic disulfide or mixed diselenide that relays electrons from the resin to the protein. This electron-relay catalysis system provides distinct advantages over the use of excess soluble reducing agent alone.

Keywords: heterogeneous catalysis; proteins; redox chemistry; selenium; sulfur

MeSH terms
Catalysis; Disulfides; Electrons; Papain; Selenium Compounds; Sulfhydryl Compounds
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